Nkhotakota Wildlife Reserve, is the largest and oldest wildlife reserve in Malawi, near Nkhotakota. The park's hilly terrain features dambos and miombo woodlands as the dominant vegetation, which support a variety of mammal and bird species. Poaching has greatly reduced the number of elephants and other large mammals in Nkhotakota, but conservation efforts to restore the elephant population started when African Parks began managing the reserve in 2015.

Nkhotakota (Un-kho-tah-kho-tuh) is a town and one of the districts in the Central Region of Malawi. It is on the shore of Lake Malawi and is one of the main ports on Lake Malawi. As of 2018, Nkhotakota had a population estimated at 28,350. The district had a population of 301.000.