Noah Gregory Centineo is an American actor and model. He is known for his roles in the final three seasons of the television series The Fosters, the Disney Channel film How to Build a Better Boy, the 2018 Netflix romantic comedy films To All the Boys I've Loved Before and Sierra Burgess Is a Loser. Centineo was born in Miami and raised in Boynton Beach, Florida, he has said he is half Italian, Dutch, "a little bit of Native American" and "there's Puerto Rican somewhere in there." He has Taylor. He attended BAK Middle School of the Arts, Boca Raton Community High School for ninth and tenth grade, where he played soccer. In 2012, he attended Agoura High School. In 2009, Centineo starred as Josh Peters, in the family film The Gold Retrievers, he had small roles in the Disney Channel sitcoms Austin & Ally and Shake It Up. Centineo subsequently co-starred as Jaden Stark in the Disney Channel romantic comedy film How to Build a Better Boy; that same year, he was cast as Ben Eastman in the Disney Channel comedy pilot Growing Up and Down, but the project was not picked up to series.
In 2015, he took over the main role of Jesus Adams Foster in Freeform's drama series The Fosters. He made his first appearance in season three's episode "Lucky", which aired on August 17, 2015. In 2017, Centineo was nominated for the Teen Choice Award for Choice Summer TV Star: Male for his performance. In 2017, Centineo began starring as Hawk Carter in go90's teen drama-thriller series T@gged, portrayed surfer/artist Johnny Sanders Jr. in the coming-of-age romantic comedy film SPF-18. That same year, he appeared as Camila Cabello's love interest in the music video for her single "Havana". Centineo starred in two Netflix original teen comedy films in 2018, he portrayed Peter Kavinsky in the adaptation of Jenny Han's romance novel To All the Boys I've Loved Before, Jamey in Sierra Burgess Is a Loser. He played the lead role of Brooks Rattigan in the Netflix film The Perfect Date, released in April 2019, he starred in the 2019 Charlie's Angels film and returning as Peter Kavinsky in To All the Boys: P.
S. I Still Love You, set to release in 2020, he will be portraying He-Man in Masters of the Universe, a film based on the franchise of the same name, to be released by Sony Pictures. In February 2020, Centineo revealed in an interview with Harper's Bazaar that he has been sober for the last couple of years, he experienced a turbulent period that started when he was 17 and ended the day before his 21st birthday. Himself describes that time as “a dark time in my life.”Also in February 2020, he launched Favored Nations, a nonprofit initiative that will utilize his social media range and influence to raise money for charity. The idea was sparked after Centineo teamed up with Omaze on a contest, which raised $280,000 for charity, offering a fan a chance to go on a hike and share a meal with him. Centineo has been in a relationship with model Alexis Ren since April 2019. Noah Centineo on IMDb Noah Centineo on Twitter
Paschim Gujarat Vij Company Ltd. is an electricity company, incorporated on 15 September 2003 by Gujarat Electricity Board. The Company obtained the Certificate of the Commencement of Business on 15 October 2003; the company was one of several created as a part of efforts towards restructuring of the power sector in the state of Gujarat in India. The company is involved in electricity sub-transmission distribution and retail supply in the State of Gujarat State, their mandate is to establish and use a power system network and to buy and sell electrical energy, to collect information with an eye towards further system improvements. The Gujarat Electricity Industry Act 2003 paved the way for comprehensive reform and restructuring of the State Electricity Board with an aim to restructure the Electricity Industry in a manner that will ensure the long term viability and sustainability of the power sector in the state; as a part of the reform process, the GEB was disaggregated into several autonomous entities.
PGVCL is undertaken by government of Gujarat The Electricity Act 2003 introduced competition by way of open access in the transmission and distribution of electricity. The Act provided for reorganization of the Electricity Boards through appropriate transfer schemes being formulated by the state governments; the Government of Gujarat reorganized the GEB functionally into a Generation Company, a Transmission Company and four Distribution Companies. Thereby Paschim Gujarat Vij Company Limited became functional on 1 April 2005. Gujarat State Electricity Corporation Limited GSEC Gujarat Energy Transmission Corporation limited Getco State Load Dispatch Center SLDC Dakshin Gujarat Vij Company Limited DGVCL Madhya Gujarat Vij Company Limited MGVCL Uttar Gujarat Vij Company Limited UGVCL Gujarat Energy Training and Research Institute GETRI www.pgvcl.com www.gseb.com
Nuclease S1 is an endonuclease enzyme that splits single-stranded DNA and RNA into oligo- or mononucleotides. This enzyme catalyses the following chemical reaction Endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-productsAlthough its primary substrate is single-stranded, it can occasionally introduce single-stranded breaks in double-stranded DNA or RNA, or DNA-RNA hybrids; the enzyme hydrolyses single stranded region in duplex DNA such as gaps. It cleaves a strand opposite a nick on the complementary strand, it has no sequence specificity. Well-known versions include S1 found in Aspergillus oryzae and Nuclease P1 found in Penicillium citrinum. Members of the S1/P1 family are found in both prokaryotes and eukaryotes and are thought to be associated in programmed cell death and in tissue differentiation. Furthermore, they are secreted extracellular, their function and distinguishing features mean they have potential in being exploited in the field of biotechnology.
Alternative names include endonuclease S1, single-stranded-nucleate endonuclease, deoxyribonuclease S1, deoxyribonuclease S1, Aspergillus nuclease S1, Neurospora crassa single-strand specific endonuclease, S1 nuclease, single-strand endodeoxyribonuclease, single-stranded DNA specific endonuclease, single-strand-specific endodeoxyribonuclease, single strand-specific DNase and Aspergillus oryzae S1 nuclease. Most nucleases with EC 3.1.30.1 activity are homologous to each other in a protein domain family called Nuclease S1/P1. Members of this family, including P1 and S1, are glycoproteins with distinguishing features, they are: a requirement for three zinc ions cofactors, containing common active site motifs and requires an acidic pH for catalysis. Contains three glycans bound to the amino acid asparagine via N-glycosylation two Disulphide bridges between cysteine residues; these requirements and distinguishing features are responsible for function efficacy. It is an enzyme and these four features are needed for enzyme functionality.
The three zinc ions are vital for catalysis. The first two zincs activate the attacking water in hydrolysis whilst the third zinc ion stabilizes the leaving oxyanion. Aspergillus nuclease, it requires Zn2+ as a cofactor and is stable against denaturing agents like urea, SDS, or formaldehyde. The optimum pH for its activity lies between 4-4.5. Aspergillus nuclease S1 is known to be inhibited somewhat by 50 μM ATP and nearly by 1 mM ATP. 50% inhibition has been shown at 85 μM dAMP and 1 μM dATP but uninhibited by cAMP. This zinc-dependent nuclease protein domain produces 5' nucleotides and cleaves phosphate groups from 3' nucleotides. Additionally, the side chain of tryptophan located in the cavity in the active site and its backbone supports the action one of the zinc ions; such mechanisms are essential to the catalytic function of the enzyme. Aspergillus nuclease. In molecular biology, it is used in removing single stranded tails from DNA molecules to create blunt ended molecules and opening hairpin loops generated during synthesis of double stranded cDNA.
Mung bean nuclease, similar activity but not homologous DNA/RNA non-specific endonuclease, non-homologous family with similar DNA/RNA activity but accepts double-stranded substrate better
David William Laing was an English writer and broadcaster, specialising in the history and development of pop and rock music. He was a research fellow at the universities of Liverpool. Laing was born in Tunbridge Wells and attended King's College School in Wimbledon, where he joined his first band, he began studies at St Catherine's College, but left in 1967 without graduating and moved to London. He started writing music articles and his first book, The Sound of Our Time, while working in clerical jobs, he took a degree in English and sociology at the University of Sussex, where he met fellow writer Phil Hardy. Laing worked with Val Wilmer on an unpublished history of coal mining communities. In 1971 he published one of the first extended analyses of Buddy Holly. At the suggestion of writer Charlie Gillett, Laing became editor of the monthly British music magazine Let It Rock, from October 1972 to October 1973, his other books include The Electric Muse: the story of Folk into Rock, One Chord Wonders: Power and Meaning in Punk Rock.
In the mid-1970s Laing was co-editor of one of the first reference books on rock music, The Encyclopedia of Rock. In 1978 he published The Marxist Theory of Art, written after moving to Hebden Bridge in Yorkshire, he co-authored, with Phil Hardy, The Faber Companion to 20th Century Popular Music, co-wrote, with Sarah Davis, The Guerrilla Guide to the Music Business. Laing was an editor of the Continuum Encyclopedia of Popular Music of the World, he wrote in music magazines and newspapers, including The Guardian. As of 2016, he was the managing editor of the journal Popular Music History and co-editor of the Icons of Pop Music book series, he died of cancer in 2019, aged 71
Tuba Azmudeh was an Iranian educator who established the first school for girls in Iran in 1907. She expanded the school, despite continuous opposition from her community. Azmudeh married an officer in the army, her husband supported her continued education, which she pursued both independently and with the help of language tutors. In 1907 or 1911, a group of women met in Tehran to discuss and work towards improving the education of girls in Iran. At the time, girls were not educated outside of their homes. Though a small number of schools for girls had been opened by foreigners as early as 1874, the Iranian government did not allow Muslim girls to attend schools until 1896. After this meeting, Azmudeh opened the first Iranian school for girls in Iran, called the Namus school, she ran the school in her home in Tehran. As it was not a state-run school, Azmudeh was responsible for protecting it herself, she and her pupils received considerable criticism from the government. Her pupils were criticized for studying outside of their own homes, accused of being prostitutes.
Azmudeh continuously received threats, both to her life and to the school, was denigrated as immoral. The Namus school expanded in size and curriculum, Azmudeh brought in her husband and friends to help teach; the school achieved some prestige, progressive Iranians began to send their daughters to study there. Azmudeh began to offer literacy classes to adult women. Azmudeh has been credited for inspiring other female educators in Iran. A number of her pupils studied to become secondary school teachers themselves
Hellboy: The Science of Evil is a video game adapted from the 2004 Hellboy film by Guillermo del Toro, based on the comic book character of the same name. It was released for the PlayStation 3, Xbox 360 and PlayStation Portable on June 24, 2008 in North America, followed by an August 15 release in Europe and August 22 release in Australia. All versions follow the same story line, however the PSP version of the game differs from the Xbox 360 and PlayStation versions. There are 3 playable characters: Hellboy, Abe Sapien, Liz Sherman. Lobster Johnson was planned to be included as a playable character, voiced by Bruce Campbell, but the DLC was never released. Herman von Klempt is the game's main villain, along with several of his'kriegaffen'; the game has online and offline multiplayer co-op for up to 2 players. The game was created under the creative direction of both the comic book's creator, Mike Mignola, the film's director, Guillermo del Toro. Ron Perlman, Selma Blair and Doug Jones reprise their roles from the film as Hellboy, Liz Sherman and Abe Sapien providing voice-overs.
Players control Hellboy in a third-person perspective as they progress through a series of levels broken up into six chapters. Levels consist of separate stages and routes occupied by multiple groups of enemies that differ between chapters. In most cases, all enemies in an area must be defeated in order to move to the next phase of the chapter, with ghostly barriers of smoke blocking paths while foes remain present. To combat opponents, Hellboy uses his stone "right hand of doom" for most hand-to-hand combat situations, with heavy and quick attacks that can be mixed together for varied combinations. Foes can be stunned, as indicated with a grey flash. Hellboy performs other attacks, such as slams and head butts, along with cinematic finishing moves when his opponent is near death; these finishing moves are necessary in the boss fights. As Hellboy defeats his enemies, he receives energy, stored in his health meter; this energy is used to execute certain grapple moves and to activate "Hellmode", where Hellboy's right hand of doom becomes engulfed in flames causing further damage in combat.
Another weapon that can be used is Hellboy's oversized pistol known as the Samaritan. The weapon fires single shots with up to nine different types of ammunition. While most kinds are for damaging opponents like "Heavy", "Grenade" and "Splinter" ammunition, others can be used during the game's puzzles like "Ignite" to light beacons or "Release" to destroy cursed vines. Additional types of ammunition like "Charge" can only be obtained by defeating certain enemies with a finishing move. Hellboy can pick up various objects on each level to be used as a projectile or weapon such as barrels, pipes and parts of enemies or their own weapons; some items are used in tasks to progress through levels such as lighting lanterns. Other puzzle elements include certain obstacles like doors and cracked walls that require Hellboy to smash through with his right hand of doom and pull levers connected to obstructions. Throughout the single player mode, there are collectables in the form of lores; these act as additional small details to the story and increase maximum energy capacity for the Hellmode ability.
The story mode can be played cooperatively with another player, both locally with another controller or online over Xbox Live for the Xbox 360 version and PlayStation Network for the PlayStation 3 version. The game's host always plays as Hellboy and can save each chapter while the second player has the choice of playing as either Abe Sapien or Liz Sherman, both with their own unique abilities and form of combat such as Abe's array of martial arts moves for combat or Liz's pyrokinesis; the plot opens in Romania where Hellboy has been sent to track a crazed witch through an abandoned graveyard inhabited by werewolves and the undead. As he battles the witch, she shapeshifts into a swarm of crows that retreats and takes refuge in the nearby village; when Hellboy arrives, he is pushed downhill into the village. The action shifts to 25 years earlier in an unknown part of rural Japan where Hellboy has been sent in to investigate reports of paranormal activity, he is attacked by an Oni. It is revealed through an old monk that the Oni's hostility is because their sacred artifact was stolen by the Nazis, under the command of Herman von Klempt, seeking to use it for their own gain.
After heading into the cliffs, Hellboy is attacked by one of Herman's Kriegaffe. Their fight continues in an old temple until Herman falls over the cliffs after accidentally being struck by a log thrown by his own minion. Hellboy returns the artifact to the old monk; the story continues back in the present in Romania with Hellboy pursuing the witch into the abandoned village, filled with the undead and Nazi robots battling one another. In a final battle with the witch in the village church, Hellboy pulls down the giant bell, crushing the witch; this is followed by the collapse of the church itself with Hellboy falling into the catacombs, where he finds a group of excavating creatures resembling an Ogdru Hem swarming with "frog monsters". Hellboy destroys the foundations of the catacombs, causing it to cave in and knocking him into an abyss; the following chapter follows Hellboy on a past mission 40 years ago in the Tunisian desert. He stumbles upon a wounded alien soldier; this time they tried to use an alien beast, but failed and though the alien is contained in a crystal prison, it was controlling the fallen Nazis in an attempt to destroy all life on Earth