The North American Atlantic Region is a floristic region within the Holarctic Kingdom identified by Armen Takhtajan and Robert F. Thorne, spanning from the Atlantic and Gulf coasts to the Great Plains and comprising a major part of the United States and southeastern portions of Canada. It is bordered by the Circumboreal floristic region in the north, by the Rocky Mountain and Madrean floristic regions in the west and by the Caribbean floristic region of the Neotropical Kingdom in the south of Florida. The flora of the region comprises two endemic monotypic families, Hydrastidaceae and Leitneriaceae, and is characterized by about a hundred of endemic genera. The degree of species endemism is very high, many species are Tertiary relicts, which survived the Wisconsin glaciation and are now concentrated in the Appalachians and the Ozarks. A number of genera are shared only with the Canadian floristic province of the Circumboreal region. Moreover, as has long been noted, a large number of relict genera are shared with the relatively distant Eastern Asiatic Region and sometimes Southeast Asia. R. F. Thorne counted at least 74 genera restricted to eastern North America and Asia. The fossil record indicates that during the Tertiary period a warm temperate zone extended across much of the Northern Hemisphere, linking America to Asia.

A phytochorion, in phytogeography, is a geographic area with a relatively uniform composition of plant species. Adjacent phytochoria do not usually have a sharp boundary, but rather a soft one, a transitional area in which many species from both regions overlap. The region of overlap is called a vegetation tension zone.