The North Carolina School of Science and Mathematics (NCSSM) is a two-year, public residential high school with two physical campuses located in Durham, North Carolina and Morganton, North Carolina that focuses on the intensive study of science, mathematics and technology. It accepts rising juniors from across North Carolina and enrolls them through senior year. Although NCSSM is a public school, enrollment is extremely selective, and applicants undergo a competitive review process for admission. NCSSM is a founding member of the National Consortium of Secondary Stem Schools (NCSSS) and a constituent institution of the University of North Carolina system.

Durham is a city in the U.S. state of North Carolina and the county seat of Durham County. Small portions of the city limits extend into Orange County and Wake County. With a population of 283,506 in the 2020 census, Durham is the 4th-most populous city in North Carolina, and the 71st-most populous city in the United States. The city is located in the east-central part of the Piedmont region along the Eno River. Durham is the core of the four-county Durham-Chapel Hill, NC Metropolitan Statistical Area, which had an estimated population of 608,879 in 2023. The Office of Management and Budget also includes Durham as a part of the Raleigh-Durham-Cary, NC Combined Statistical Area, commonly known as the Research Triangle, which had an estimated population of 2,368,947 in 2023.