North Central Timor Regency is a regency in East Nusa Tenggara Province, Indonesia. It covers an area of 2,669.70 km2, and had a population of 229,803 at the 2010 Census and 259,829 at the 2020 Census; the official estimate as at mid 2023 was 271,277. Its regency seat is located at the town of Kefamenanu, which had a population of 49,589 in mid 2023. The regency borders Timor Leste's Oecusse enclave, one of few Indonesian regions that have a land border with other countries.

East Nusa Tenggara is the southernmost province of Indonesia. It comprises the eastern portion of the Lesser Sunda Islands, facing the Indian Ocean in the south and the Flores Sea in the north. It consists of more than 500 islands, with the largest ones being Sumba, Flores, and the western part of Timor; the latter shares a land border with the separate nation of East Timor. The province is subdivided into twenty-one regencies and the regency-level city of Kupang, which is the capital and largest city.