The North Slave Region or Tłicho Region is one of five administrative regions in the Northwest Territories of Canada. It is the most populous of the five regions, with a population of almost 23,000. According to Municipal and Community Affairs the region consists of eight communities with the regional office situated in Yellowknife and a sub-office in Behchokǫ̀. With the exception of Yellowknife, the communities are predominantly First Nations.

Yellowknife is the capital, largest community, and only city in the Northwest Territories, Canada. It is on the northern shore of Great Slave Lake, about 400 km (250 mi) south of the Arctic Circle, on the west side of Yellowknife Bay near the outlet of the Yellowknife River.