The North Wales Main Line, also known as the North Wales Coast Line, is a major railway line in the north of Wales and Cheshire, England, running from Crewe on the West Coast Main Line to Holyhead on the Isle of Anglesey. The line has 19 stations, with all except two, Chester and Crewe, being in Wales.

Holyhead is the largest town and a community in the county of Isle of Anglesey, Wales, with a population of 13,659 at the 2011 census.. Holyhead is on Holy Island, bounded by the Irish Sea to the north, and is separated from Anglesey island by the narrow Cymyran Strait and was originally connected to Anglesey via the Four Mile Bridge.