Northeastern State University (NSU) is a public university with its main campus in Tahlequah, Oklahoma. The university also has two other campuses in Muskogee and Broken Arrow as well as online. Northeastern is the oldest institution of higher learning in the state of Oklahoma as well as one of the oldest institutions of higher learning west of the Mississippi River. Tahlequah is home to the capital of the Cherokee Nation of Oklahoma and about 25 percent of the students at NSU identify themselves as American Indian. The university has many courses focused on Native American linguistics, and offers Cherokee language Education as a major. Cherokee can be studied as a second language, and some classes are taught in Cherokee for first language speakers as well.

Tahlequah is a city in Cherokee County, Oklahoma located at the foothills of the Ozark Mountains. It is part of the Green Country region of Oklahoma and was established as a capital of the 19th-century Cherokee Nation in 1839, as part of the new settlement in Indian Territory after the Cherokee Native Americans were forced west from the American Southeast on the Trail of Tears.