Northenden is a suburb of Manchester, Greater Manchester, England, with a population of 14,771 at the 2011 census. It lies on the south side of the River Mersey, 4 miles (6.4 km) west of Stockport and 5 miles (8.0 km) south of Manchester city centre, bounded by Didsbury to the north, Gatley to the east, Sale to the west and Wythenshawe to the south.

The River Mersey is a major river in North West England. Its name derives from Old English and means "boundary river", possibly referring to its having been a border between the ancient kingdoms of Mercia and Northumbria. For centuries it has formed part of the boundary between the historic counties of Lancashire and Cheshire.