The Northern General Hospital is a large teaching hospital and Major Trauma Centre in Sheffield, England. Its departments include Accident and Emergency for adults, with children being treated at the Sheffield Children's Hospital on Western Bank. The hospital is managed by the Sheffield Teaching Hospitals NHS Foundation Trust.

The Hillsborough disaster was a fatal crowd crush at a football match at Hillsborough Stadium in Sheffield, South Yorkshire, England, on 15 April 1989. It occurred during an FA Cup semi-final between Liverpool and Nottingham Forest in the two standing-only central pens within the Leppings Lane stand allocated to Liverpool supporters. Shortly before kick-off, police match commander David Duckenfield ordered exit gate C to be opened in an attempt to ease crowding, which led to an influx of supporters entering the pens. This resulted in overcrowding of those pens and the fatal crush; with a total of 97 fatalities and 766 injuries, the disaster is the deadliest in British sporting history. Ninety-four people died on the day; another person died in hospital days later, and another died in 1993. In July 2021, a coroner ruled that Andrew Devine, who died 32 years later, after suffering severe and irreversible brain damage on the day, was the 97th victim. The match was abandoned and restaged at Old Trafford in Manchester on 7 May 1989; Liverpool won and went on to win that season's FA Cup.