The Northern Iowa Panthers football represents the University of Northern Iowa in college football at the NCAA Division I Football Championship Subdivision (FCS) level as member of the Missouri Valley Football Conference (MVFC). The program began in 1895 and has fielded a team every year since with the exceptions of 1906–1907 and 1943–1944. The Panthers play their home games at the UNI-Dome on the campus of the University of Northern Iowa, in Cedar Falls, Iowa.

The NCAA Division I Football Championship is an annual post-season college football game, played since 2006, used to determine a national champion of the NCAA Division I Football Championship Subdivision (FCS). From 1978 to 2005, the game was known as the NCAA Division I-AA Football Championship.