Northwest High School (NWHS) is a public high school in Germantown, Maryland. It is part of the Montgomery County Public Schools public school system. As of 2019, its enrollment was around 2,650 students. It is one of two high schools in Germantown, the other being Seneca Valley High School, with which Northwest shares an athletic rivalry. The school also serves small sections of the cities of Gaithersburg and Darnestown.

Germantown is an urbanized census-designated place in Montgomery County, Maryland. With a population of 91,249 as of the 2020 census, it is the third most populous place in Maryland, after Baltimore and Columbia. Germantown is located approximately 28 miles (45 km) outside the U.S. capital of Washington, D.C., and is an important part of the Washington metropolitan area.