Northwestern State University of Louisiana (NSULA) is a public university primarily situated in Natchitoches, Louisiana, with a nursing campus in Shreveport and general campuses in Leesville/Fort Johnson and Alexandria. It is a part of the University of Louisiana System.

Natchitoches, officially the City of Natchitoches, is a small city and the parish seat of Natchitoches Parish, Louisiana, United States. At the 2020 United States Census, the city's population was 18,039. Established in 1714 by Louis Juchereau de St. Denis as part of French Louisiana, the community was named after the indigenous Natchitoches people.