The Nottingham–Grantham line is a branch line between the city of Nottingham and the town of Grantham in the East Midlands of England. For most of its length it runs parallel to the A52.

The A52 is a major road in the East Midlands, England. It runs east from a junction with the A53 at Newcastle-under-Lyme near Stoke-on-Trent via Ashbourne, Derby, Stapleford, Nottingham, West Bridgford, Bingham, Grantham, Boston and Skegness to the east Lincolnshire coast at Mablethorpe. It is approximately 147 miles (237 km) long.