Nové Mesto nad Váhom District is a district in the Trenčín Region of western Slovakia. Before 1920, the territory of the district was mostly part of the county of Kingdom of Hungary of Nyitra, with an area in the north forming part of the county of Trencsén.

The Trenčín Region is one of the eight Slovak administrative regions. It consists of nine districts (okresy). The region was established in 1996: previously it had been a part of the West Slovak Region and partly the Central Slovak Region. Industry is a major sector of the region's economy.