Nueces County is located in the U.S. state of Texas. As of the 2020 census, the population was 353,178, making it the 16th-most populous county in the state. The county seat is Corpus Christi. The county was formed in 1846 from portions of San Patricio County and organized the following year. It is named for the Nueces River, which marks the county's northwestern boundary with San Patricio County before emptying into its mouth at Nueces Bay north of the port of Corpus Christi. Nueces County is part of the Corpus Christi metropolitan statistical area.

Corpus Christi is a coastal city in the South Texas region of the U.S. state of Texas and the county seat and largest city of Nueces County with portions extending into Aransas, Kleberg, and San Patricio counties. It is 130 miles (210 km) southeast of San Antonio and 208 miles (335 km) southwest of Houston. Its political boundaries encompass Nueces Bay and Corpus Christi Bay. Its zoned boundaries include small land parcels or water inlets of three neighboring counties.