The Nymphenburg Porcelain Manufactory, is located at the Nördliche Schloßrondell in one of the Cavalier Houses in front of the Nymphenburg Palace in Munich and since its establishment in 1747 has produced porcelain of high quality. It is one of the last porcelain producers in the world where every single part is made by hand. After his accession in 1745 Maximilian III Joseph, Prince-Elector of Bavaria, commanded the establishment of manufacturing companies in order to bail out the state finances. On 11 November 1747 the first manufactory with potters and modelling shops and writing rooms was set up at the Grüne Schlössl, Neudeck Castle located in the area of the modern day Munich borough of Au-Haidhausen. Not until 1754 after Joseph Jakob Ringler had mastered the complex processes of production, regular manufacture of porcelain began to succeed. In the same year the rococo porcelain sculptor Franz Anton Bustelli came to work at the factory. In 1755 the factory received its first commission from the Bavarian court and in 1756 came the first success in painting the porcelain in colour.

The skillfull management of lawyer and entrepreneur Count Sigmund von Haimhausen ensured that by 1758 the factory was placed on a sound commercial footing. In 1761 the manufacture moved to a Cavalier house, a prestigious two-storey hipped roof building with a semicircular risalit center and structured plaster on the grand circle near the main entrance of the Nymphenburg Palace, where it is still located today. Among the artists who followed Bustelli were Johann Peter Melchior. A great promoter of the works was Ludwig I. Particular favourites were dinner services with copies of famous paintings or with Bavarian landscapes in an antique style. In 1822 Friedrich von Gärtner, the fashionable architect, was appointed artistic director of the factory. In the middle of the 19th century its financial position deteriorated to the extent that in 1856 all artistic production was halted and it was decided to privatise the factory, it was leased out for the first time in 1862 and its focus shifted to the production of technical and sanitary porcelain goods.

In 1887 Albert Bäuml took a lease of the factory. His aim was to regain the previous high artistic level of the factory's products: it was Bäuml, for example, who "rediscovered" Bustelli; this aim was realised at around the turn of the 19th and 20th centuries and besides historical copies, elegant Jugendstil ceramics were developed. The product range includes services, mocca cups, animal figurines, baskets, maiolica, table decoration and accessories; the customers of these exquisite products include the international aristocracy, embassies and palaces at home and abroad. Since 1975 the factory has been leased by the Bavarian government to the Wittelsbach Compensation Fund. In 2011 it was taken over by Prince Luitpold of Bavaria; the Nymphenburg Palace accommodates the Nymphenburg Porcelain Museum. Guided tours through the factory can be arranged by prior appointment. Nymphenburg Palace is known to have been the working place of artists and sculptors like Hanns Goebl and Franz Anton Bustelli. Marita Krauss: Die königlich-bayerischen Hoflieferanten.

Volk Verlag, Munich 2008, ISBN 978-3-937200-27-9, Katharina Hantschmann: Nymphenburger Porzellan 1797 bis 1847. Geschichte, Dekore. Klinkhardt und Biermann, Munich 1996, ISBN 3-7814-0390-4, Friedrich H. Hofmann: Geschichte der bayerischen Porzellan-Manufaktur Nymphenburg. 3 Volumes. Hiersemann, Leipzig 1921–1923, reprint: Scherer, Edition Arkanum, Berlin 1991, ISBN 3-89433-009-0. Barbara Krafft, Max Oppel: 250 Jahre Porzellan-Manufaktur Nymphenburg 1747 – 1997. IP-Verlags-Gesellschaft, Munich 1997, ISBN 3-00-001191-9. Timo Nüßlein: Paul Ludwig Troost. Böhlau, Wien u. a. 2012, ISBN 978-3-205-78865-2, Timo Nüßlein: Der „Erste Baumeister des Dritten Reichs“ und das Porzellan – Paul Ludwig Troost und die Staatliche Porzellanmanufaktur Nymphenburg, in: Keramos 220, ISSN 0453-7580, Gesellschaft der Keramikfreunde, Deggendorf 2013. Arno Schönberger: Nymphenburger Porzellan. Prestel, Munich 1949. Rainer Schuster: Nymphenburger Porzellan. Kostbarkeiten aus der Sammlung Bäuml und dem Residenzmuseum Munich. Bayerische Verwaltung der staatlichen Schlösser, Gärten und Seen, Munich 1997, ISBN 3-9805654-0-8.

Rosel Termolen: Nymphenburger Porzellan. 3. Auflage. Rosenheimer, Rosenheim 1997, ISBN 3-475-52504-6, Hans Thoma: Porzellan-Manufaktur Nymphenburg. 1747–1947. Zweihundert Jahre Nymphenburg. Bruckmann, Munich 1947. Alfred Ziffer: Nymphenburger Porzellan. Sammlung Bäuml. Arnold, Stuttgart 1997, ISBN 3-925369-61-9. Rainer Schuster, 1997. Nymphenburger Porzellan. Kostbarkeiten aus der Sammlung Bäuml und dem Residenzmuseum München. Munich: Bayerische Verwaltung der staatlichen Schlösser, Gärten und Seen. Nymphenburg Porcelain Manufactory official website Museum Nymphenburger Porzellan – Bavarian Administration of State-Owned Palaces and Lakes Porcelain manufacturing companies in Europe

An HIV vaccine may have the purpose of protecting individuals who do not have HIV from being infected with the virus, or treating an HIV-infected person. There are two approaches to an HIV vaccine: an active vaccination approach in which a vaccine aims to induce an immune response against HIV. There is no licensed HIV vaccine on the market, but multiple research projects are trying to find an effective vaccine. There is evidence from humans. Some, but not all, HIV-infected individuals produce broadly neutralizing antibodies which keep the virus suppressed and these people remain asymptomatic for decades. Potential broadly neutralizing antibodies have been cloned in the laboratory and are being tested in passive vaccination clinical trials. Many trials have shown no efficacy but one HIV vaccine regimen, RV 144, has been shown to prevent HIV in some individuals in Thailand; the urgency of the search for a vaccine against HIV stems from the AIDS-related death toll of over 35 million people since 1981.

In 2002, AIDS became the primary cause of death due to an infectious agent in Africa. Alternative medical treatments to a vaccine exist. For the treatment of HIV-infected individuals, Highly Active Antiretroviral Therapy medication has been demonstrated to provide many benefits to HIV-infected individuals, including improved health, increased lifespan, control of viremia, prevention of transmission to babies and partners. HAART must be taken lifelong without interruption to be effective, cannot cure HIV. Options for the prevention of HIV infection in HIV-uninfected individuals include safer sex, antiretroviral strategies and medical male circumcision. Vaccination has proved a powerful public health tool in vanquishing other diseases, an HIV vaccine is considered as the most and the only way by which the HIV pandemic can be halted. However, HIV remains a challenging target for a vaccine. In 1984, after the confirmation of the etiological agent of AIDS by scientists at the U. S. National Institutes of Health and the Pasteur Institute, the United States Health and Human Services Secretary Margaret Heckler declared that a vaccine would be available within two years.

However, the classical vaccination approach, successful in the control of other viral diseases - priming the adaptive immunity to recognize the viral envelope proteins - did not work against HIV. Many factors make the development of an HIV vaccine different from other classic vaccines: Classic vaccines mimic natural immunity against reinfection as seen in individuals recovered from infection. Most vaccines protect against disease, not against infection. Most effective vaccines are live-attenuated organisms; the epitopes of the viral envelope are more variable than those of many other viruses. Furthermore, the functionally important epitopes of the gp120 protein are masked by glycosylation and receptor-induced conformational changes making it difficult to block with neutralizing antibodies; the ineffectiveness of developed vaccines stems from two related factors: First, HIV is mutable. Because of the virus' ability to respond to selective pressures imposed by the immune system, the population of virus in an infected individual evolves so that it can evade the two major arms of the adaptive immune system.

Second, HIV isolates are themselves variable. HIV can be categorized into multiple subtypes with a high degree of genetic divergence. Therefore, the immune responses raised by any vaccine need to be broad enough to account for this variability. Any vaccine that lacks this breadth is unlikely to be effective; the difficulties in stimulating a reliable antibody response has led to the attempts to develop a vaccine that stimulates a response by cytotoxic T-lymphocytes. Another response to the challenge has been to create a single peptide that contains the least variable components of all the known HIV strains; the typical animal model for vaccine research is the monkey the macaque. Monkeys can be infected with the chimeric SHIV for research purposes. However, the well-proven route of trying to induce neutralizing antibodies by vaccination has stalled because of the great difficulty in stimulating antibodies that neutralise heterologous primary HIV isolates; some vaccines based on the virus envelope have protected chimpanzees or macaques from homologous virus challenge, but in clinical trials, humans who were immunised with similar constructs became infected after exposure to HIV-1.

There are some differences between SIV and HIV that may introduce challenges in the use of an animal model. The animal model can be useful but at times controversial. There is a new animal model resembling that of HIV in humans. Generalized immune activation as a direct result of activated CD4+ T cell killing - performed in mice allows new ways of testing HIV behaviour. NIAID-funded SIV research has shown that challenging monkeys with a cytomegalovirus -based SIV vaccine results in containment of virus. Virus replication and dissemination occurs within days after infection, whereas vaccine-induced T cell activation and recruitment to sites of viral replica

Carl and Wilhelm Blumwe were successful German entrepreneurs and businessmen in Bromberg from the second half of the 19th century. Their buildings and realizations are still standing today in the city. Carl was born on October 1827 in Chojnice. In his youth, he moved to Erfurt, he arrived in Bydgoszcz as a foreman in the Prussian Eastern Railway, around 1850, lived at Dworcowa Street 42. In 1865, he opened his own construction and repair workshop for agricultural machinery, which moved in 1869 to a plot at Jagiellońska street 94, it was a small foundry, specialized in the manufacture of patent axle wagon and woodworking machines. In 1878, he bought from Julius Schmidt a small iron foundry on Nakelerstraße, expanded it and installed steam engines. In 1878, the firm took the name of C. Blumwe and Son, since his son Wilhelm took over the management in the early 1880s. In 1884, the name changed to C. Blumwe and Son - Iron Foundry Specialized in patent axle wagon and woodworking machines: it is the ground base of today's Machine Tools Factory for Wood.

Soon, the facility was focused only to the production of saws, woodworking machines and steam engine. Thanks to its expertise and its excellent quality the company gained considerable notoriety: in 1886, it employed more than 100 workers. Carl Blumwe died on March 1887 in Bydgoszcz; the urn with his ashes was placed on top of his son's villa in downtown. Carl Blumwe was married to Louise Heinrich, had several children. Franz Julius Wilhelm Blumwe was born on August 1853 in Erfurt. In Bydgoszcz, he attended in the mid-1850s his gymnasium and graduated in 1871, he studied mechanical engineering in Germany in England and Denmark. He returned to Bydgoszcz in 1878. After his father's death in 1887, Wilhelm expanded workshops factory, installing lighting and electrical transmission equipment. In 1896, he built a state-of-the-art iron foundry iron. In 1897, the firm was changed to a Joint Stock Company, with Wilhelm as main shareholders and director. At the end of the 19th century, the C. Blumwe and Son firm had branches in Berlin and Cologne.

Production was shipped throughout Europe, to China, United States and Africa. In 1899, the factory employed 250 workers. At its climax, the firm owned additional plots on the northern side of Nakielska street, in front of the factory, used as storing area. In addition to his business, Wilhelm was involved in social and charity movement. In 1889, workers with more than 10 years of employment at the factory received a savings account with 50 DM, he created a health insurance system and a funeral cash system for his workers. In 1900, he established a home care for employees' children in a nearby villa, he was a member of the National Liberal Party, but did not take an active part in political activities. For many years, he acted in the local Chamber of Commerce and became a Member of the Board in 1897, he participated in the works of the Historical Society of the Netze District and Bromberg's German Society of Arts and Sciences. In both societies, he served as a board member. In the years 1896-1897 he built his house at Gdańska Street 50, where he lived with his wife and mother.

He married in 1880 Marie Christiane Clara Strelow, daughter of Julius Strelow, owner of a local brewery. They did not have children. Wilhelm died on September 1903 in Bromberg, his company survived him till today. Registered on the Kuyavian-Pomeranian heritage list. A/1129, July 8, 1992 and September 29, 1998 1900–1904, by Hildebrandt. Gdańska Street 50 The building was erected between 1900 and 1904 by architect Hildebrandt from Berlin; the investor was son of Carl Blumwe. The building has the classical shape of a palace, with a style referring to Palladian architecture, popular in Europe in the late 19th century. 1850s–1890s, reconstruction by Carl Stampehl Nakielska street 53 Neo-Baroque The Villa Carla Blumwe is a former industrial building that belonged to factory managers Carl and Wilhelm Blumwe. The building is located at Nakielska street 53 in Bydgoszcz, its architectural features can be connected with identical industry-related edifices from the second half of the 19th century in Lodz and Warsaw.

The construction of the Villa happened in several stages, led by the successful development of the neighbouring "Factory of Machine Tools for wood", on which plot it has been built. The oldest part of the premises, made of wattle and daub, was built in the 1850s, while its north façade, erected only in 1879, is made of bricks as a single-storey building with a separate entrance. On December 12, 1892, Wilhelm Blumwe applied for the reconstruction and expansion of his a dwelling house, he asked a master mason and carpenter, to realize this project. At this time, Carl Stampehl was known for designing tenements in Gdańska Street. For the villa, Carl Stampehl carried out in 1893: the reconstruction of the old house's interior. A tower was added on the western part, along with a new wing devoted to business offices. All architectural details on the facade were revamped. Another building addition was performed in 1900. After World War II, an intensive refurbishing outside and inside has obliterated a major part of architectural details.

Throughout its existence, the villa was part of "Factory of Machine Tools for wood". The building design refers to rich neo-Baroque villas; the oldest eastern part has an asymmetrical facade, with a wooden cornice supported by corbels and a wattle and daub wall, filled with cerami

John Normington was an English actor primary known for his work on television. Normington was a member of the Royal Shakespeare Company performing in more than 20 RSC productions, he performed in the West End and at the National Theatre. Normington was born in Dukinfield, Cheshire, in 1937 where he resided in Montrose Avenue with his parents and two younger sisters Judith and Joan, he attended Victoria Road Infants School before transferring to Globe Lane County Primary on to Crescent Road Boys School. He trained as an opera singer at the Northern School of Music. Following this, he did his national service and while stationed in Aldershot joined Farnham rep. Normington joined the Repertory Theatre in Oldham in 1950, from 1959 to 1962 he worked at the Library Theatre in Manchester. After a short spell at the Oxford Playhouse, John Normington joined the Royal Shakespeare Company in 1963 and played many Shakespearean roles, he continued on stage for the rest of his life, with many memorable roles.

In 1963, he made his first appearance on television. In the 1960s and 1970s, he appeared in programmes such as Murder Most English, his film credits included roles in Inadmissible Evidence, A Midsummer Night's Dream, The Reckoning, Rollerball, The Medusa Touch, The Thirty Nine Steps, A Private Function, Hitler's S. S.: Portrait in Evil as Himmler, My Family and Other Animals, Jack the Ripper and Wilt. During the 1980s, he appeared in Play for Today. Normington played Morgus in the 1984 Doctor Who serial The Caves of Androzani and Trevor Sigma in the 1988 serial The Happiness Patrol; the following decade, Normington played roles in programmes such as The New Statesman. In 2001 John Normington appeared in Love in a Cold Climate. In 2004, Normington appeared in King Lear in Stratford. Before the production moved to the West End, he had to withdraw after developing pancreatic cancer, he recovered to an extent that he took on further roles on screen. On stage he appeared in The Voysey Inheritance in 2006 and The Entertainer from March to April 2007, before he pulled out due to ill health.

On screen, he appeared in the 2004 Midsomer Murders episode. John Normington died, of pancreatic cancer, on 26 July 2007 in the Chelsea and Westminster Hospital, London aged 70, his partner was John Anderson. The Thirty Nine Steps The Medusa Touch A Private Function John Normington on IMDb John Normington at the Internet Broadway Database List of Royal Shakespeare Company performances

Wendee Lee is an American voice actress and director in the animation industry and video games.. She voiced Scorpina on the live-action Mighty Morphin Power Rangers. Lee grew up in the Los Angeles area, in San Francisco, she studied dance and theater and became a full-time dancer in her teens. According to her interview on the Magic Knight Rayearth DVDs, she started doing voices at school, got in trouble for it, her first anime voice role was in Harmony Gold production Robotech in the 1980s, where she voiced Vanessa Leeds, one of the operators aboard the SDF-1 Macross. She worked with Streamline on several anime productions including Dragon Ball She would continue dance, work part-time as a make-up artist and dance instruction. Lee's major voice roles in anime include Kei in the Pioneer dub of Akira, Faye Valentine on Cowboy Bebop, Myōjin Yahiko in Rurouni Kenshin, Takeru "T. K." Takaishi on Digimon Adventure, Haruhi Suzumiya on The Melancholy of Haruhi Suzumiya and Konata Izumi on Lucky Star. She has worked as an ADR director on Bleach, Love Hina and Outlaw Star and a casting director on The Night B4 Christmas.

In 2014-2015, she voiced Queen Serenity in the Viz Media re-dub of the classic Sailor Moon series and the new Sailor Moon Crystal series. Jeng, Way. "Being a Brief Discussion of Anime Dubs: Ai Yori Aoshi: Enishi, Volume Two". Mania. Demand Media. Archived from the original on November 5, 2014. Martin, Theron. "Iczer-One DVD". Anime News Network. Wendee Lee interview on Anime Herald Wendee Lee interview on Gamasutra Wendee Lee interview Gamasutra Wendee Lee on Twitter Wendee Lee at Anime News Network's encyclopedia Wendee Lee at Crystal Acids Wendee Lee on IMDb

Rie Miyazawa is a Japanese actress and former fashion model and singer. She has done glamour modeling too, she is well known as former fiancé of sumo wrestler Takanohana, to whom she was engaged for 2 months, for her years of fighting anorexia nervosa. Rie Miyazawa was born in Tokyo to a Japanese mother. Since her debut at age 11 in an advertisement for Kit Kat, she has many films, television shows, stage appearances and photo books to her credit, she starred in the children's comedy Bokura Tokyo Elevator Girl. Miyazawa made her debut as a singer on September 15, 1989, with her debut album MU, she gained notoriety in 1991 with the publication of a Fine art nude photography book, Santa Fe, more publicity in 1992 by her engagement to sumo star Takanohana. The engagement was called off in 1993. In September 1994 she cut her wrists with a broken glass in what she described as an "accident"; the tabloids focused on Miyazawa's drinking session, fights with her mother, her escape to a nearby hotel as signs of a suicide attempt.

Miyazawa continued to pursue her career as an actress, including a performance in Kon Ichikawa's movie Chushingura that year. But the following February she pulled out of the drama Kura and in November backed out of the musical Kyote. In early 1996 Miyazawa moved to Coastal California, but by May she was back on TV reporting from the Cannes Film Festival and that year she appeared in two TV dramas: Hanayome Kaizoebito and Kyosokyoku. In 1997 she made Mikeneko Homes Hoteru and appeared on stage. In 2001, Miyazawa won the Best Actress Award at the 23rd Moscow International Film Festival by portraying a Chinese Kunqu performer in the Hong Kong film Peony Pavilion, directed by Yonfan. In 2002, she starred alongside Hiroyuki Sanada in Tasogare Seibei, the year's hit movie that won numerous awards at home, including ones for the lead actors, was nominated for an Academy Award as Best Foreign Language Film. In 2003 she played the role of Oshino in the NHK TV series Musashi. Tony Takitani — an adaptation of a short story by bestselling author Haruki Murakami — received critical acclaim, with Miyazawa playing two roles alongside Issey Ogata.

The film, entered at the Sundance Film Festival, has been described as "a controlled minimalist film masterpiece". In 2005, she starred as Tsubaki in Ashurajō no Hitomi, a movie adaptation of a 16th-century play. Most she received the 40th Japan Academy Prize for Best Actress for her performance in Her Love Boils Bathwater. On February 13, 2009, she announced to the public that she was six months pregnant and would soon marry the father of the child, reported to be Hiroyuki Nakatsu, an ex-pro surfer from Hawaii turned entrepreneur. On May 20, 2009 in Tokyo she gave birth to a baby girl. On March 23, 2016, she announced. Seven Days' War — Hitomi Nakayama Who Do I Choose? Basara: The Princess Goh Erotic Liaisons Kin chan no Cinema Jack II: Light of Firefly 47 Ronin Tenshu monogatari The Cabbie Peony Pavilion Free and Easy 12: Big Holiday Bonus Project Utsutsu The Twilight Samurai The Face of Jizo Tony Takitani Ashurajō no Hitomi The Book of the Dead —Voice Hana The Invitation from Cinema Orion Yume no Manimani Haha Shan no Komoriuta Gelatin Silver LOVE Kiki's Delivery Service Pale Moon Her Love Boils Bathwater No Longer Human Seven Days War — Hitomi Nakayama Kasuga no Tsubone — young Ohatsu Kita no Kuni kara: Himitsu "Concerto" Kita no Kuni kara: Jidai Kita no Kuni kara: Yuigon Gō — Yodo-dono Gu-Gu Datte Neko de Aru Sherlock Holmes The Hunchback of Notre Dame II — Madellaine Oceans — Narrator Gypsy Kaijin Bessō Tenshu monogatari Furu-amerika ni Sode wa Nurasaji Tezuka's Ancestor Dr. Ryoan Rainbow Parakeet The Tale of Genji The Kiss of an Invisible Man Rope Dorakuru－God Fearing Dracul A Doll's House Piper The Character A Doll's House Yomiuri Theater Award—Best Actress Rope The 41st Kinokuniya Stage Award—Individual Award Art Encouragement Prize for 2004—from Agency for Cultural Affairs The Face of Jizō Blue Ribbon Award—Best Actress Kinema Junpo Awards—Best Actress Yamaji Fumiko Award—Best Actress The Kiss of an Invisible Man Yomiuri Theater Award—Best Actress Twilight Samurai Japan Academy Award—Best Actress Blue Ribbon Award—Best Supporting Actress Nikkan Sports Movie Award—Best Actress Kinema Junpo Awards—Best Actress Mainichi Film Concours—Best Supporting Actress Hochi Film Award—Best Actress Utsutsu Kinema Junpo Awards—Best Actress Blue Ribbon Award—Best Supporting Actress Peony Pavilion Moscow International Film Festival—Best Actress Seven Days' War Japan Academy Award—Best New Actor Nikkan Sports Movie Award—Best New Talent Who Do I Choose?

Nikkan Sports Film Award—Best New Talent Profile at Japan Zone Miyazawa Rie on IMDb Metropolis – Big in Japan: Rie Miyazawa Idol*80 Discography Sharp, Jasper. "Erotic Liaisons". Midnighteye.com. Retrieved May 14, 2007