The Libertador General Bernardo O'Higgins Region, often shortened to O'Higgins Region, is one of Chile's 16 first order administrative divisions. It is subdivided into three provinces. It is named in honour of Bernardo O'Higgins Riquelme, one of Chile's founding fathers.

Bernardo O'Higgins Riquelme was a Chilean independence leader who freed Chile from Spanish rule in the Chilean War of Independence. He was a wealthy landowner of Basque-Spanish and Irish ancestry. Although he was the second Supreme Director of Chile (1817–1823), he is considered one of Chile's founding fathers, as he was the first holder of this title to head a fully independent Chilean state.