Of Mice and Men is a 1992 American period drama film based on John Steinbeck's 1937 novella of the same name. Directed and produced by Gary Sinise, the film features Sinise as George Milton, alongside John Malkovich as Lennie Small, with Casey Siemaszko as Curley, John Terry as Slim, Ray Walston as Candy, Joe Morton as Crooks, and Sherilyn Fenn as Curley's wife.

Of Mice and Men is a 1937 novella written by American author John Steinbeck. It narrates the experiences of George Milton and Lennie Small, two displaced migrant ranch workers, who move from place to place in California in search of new job opportunities during the Great Depression in the United States.