The Ohio River flood of 1937 took place in late January and February 1937. With damage stretching from Pittsburgh, Pennsylvania, to Cairo, Illinois, 385 people died, one million people were left homeless and property losses reached $500 million. Federal and state resources were strained to aid recovery as the disaster occurred during the depths of the Great Depression and a few years after the beginning of the Dust Bowl.

Jeffersonville is a city and the county seat of Clark County, Indiana, United States, situated along the Ohio River. Locally, the city is often referred to by the abbreviated name Jeff. It lies directly across the Ohio River to the north of Louisville, Kentucky, along I-65. The population was 49,447 at the 2020 census.