State Route 154 (SR 154) is a 16.27-mile-long (26.18 km) Ohio State Route that runs between Lisbon and the Pennsylvania state line in the US state of Ohio. Some of the highway is listed on the National Highway System. Most of the route is a rural two-lane highway and passes through both farmland and woodland. The highway was first signed in 1923 on a route that is now SR 517 and SR 558. SR 154 was rerouted in 1926 to its current alignment. Two section of the highway was paved in 1929, with the rest of the route was paved in 1933.

Lisbon is a village in and the county seat of Columbiana County, Ohio, United States, along the Little Beaver Creek. The population was 2,597 at the 2020 census. It is a part of the Salem micropolitan area, about 23 miles (37 km) southwest of Youngstown.