State Route 285 is a 28.03-mile (45.11 km) long state highway in eastern Ohio. The route runs from SR 821 in Caldwell, Ohio, the county seat of Noble County, to US 22 in Madison Township, Guernsey County.

State Route 821 (SR 821) is a north–south state highway in the southeastern portion of the U.S. state of Ohio. A state-maintained section of the old US 21, its southern terminus is at SR 60 approximately 2 miles (3.2 km) north of Marietta, and its northern terminus is at I-77 in Byesville, along with the eastern terminus of SR 209. The route is entirely undivided surface road, and is much less direct than the newer I-77 which supplanted it as a through route. As the interstate was being built, the designation of US 21 was moved to the freeway before Ohio wholly decommissioned the now-superfluous U.S. route. SR 821 was designated about two years after US 21 was moved onto I-77 in southeastern Ohio.