State Route 39 is a primarily east–west running state highway in north-central and northeastern portion of the U.S. state of Ohio. The route runs through seven counties on its approximately 155-mile (249 km) trip through the region. Its western terminus is at State Route 103 near New Washington, and its eastern terminus is at PA 68 near East Liverpool.

U.S. Route 250 (US 250) is a United States Numbered Highway that runs from Sandusky, Ohio to Richmond, Virginia. Within the state of Ohio, the route runs from US 6 in Sandusky to the West Virginia border at Bridgeport.