State Route 60 is a north–south state highway that runs the entire length of the U.S. state of Ohio, from the Williamstown Bridge over the Ohio River in Marietta to U.S. Route 6 near Lake Erie in Vermilion. It is the seventh longest state route in Ohio.

Marietta is a city in, and the county seat of, Washington County, Ohio, United States. It is located in southeastern Ohio at the confluence of the Muskingum and Ohio Rivers, 11 miles (18 km) northeast of Parkersburg, West Virginia. As of the 2020 census, Marietta has a population of 13,385 people. It is the principal city of the Marietta micropolitan area, which includes all of Washington County, and is the second-largest city in the Parkersburg–Marietta–Vienna combined statistical area.