State Route 7 (SR 7), formerly known as Inter-county Highway 7 until 1921 and State Highway 7 in 1922, is a north–south state highway in the southern and eastern portions of the U.S. state of Ohio. At about 336 miles (541 km) in length, it is the longest state route in Ohio. Its southern terminus is an interchange with U.S. Route 52 (US 52) just west of Chesapeake. Its northern terminus also serves as the eastern terminus of SR 531 in Conneaut. The path of SR 7 stays within five miles (8.0 km) of the Ohio River for the southern portion, with the river being visible from much of the route. The road also remains within 10 miles (16 km) of the Pennsylvania state line for the northern portion.

U.S. Route 52 runs east–west across the southern part of the state of Ohio along the Ohio River, passing through or very near the cities and towns of Cincinnati, Portsmouth, and Ironton. For its first 19 miles (31 km) or so, the highway runs concurrently with Interstate 74 (I-74) and I-75 before it winds through downtown Cincinnati for several miles. The route is primarily two lanes between New Richmond and West Portsmouth, Ohio, where it becomes a four-lane partial access highway until it exits the state near Chesapeake.