The Old Indian Meeting House is a historic meeting house at 410 Meetinghouse Road in Mashpee, Massachusetts. Built in 1758, the meetinghouse is the oldest Native American church in the eastern United States. The building was listed on the National Register of Historic Places in 1998.

Mashpee is a town in Barnstable County, Massachusetts, United States, on Cape Cod. The population was 15,060 as of 2020. The town is the site of the headquarters and most members of the Mashpee Wampanoag Tribe, one of two federally recognized Wampanoag groups.