The Old Medical College Building is a historic academic building at 598 Telfair Street in Augusta, Georgia, US. It was built in 1835 for the Medical College of Georgia, then and now one of the leading medical schools of the American South. It was declared a National Historic Landmark in 1996 for its sophisticated Greek Revival architecture, and for the role the school played in the establishment of the American Medical Association and the standardization of medical practices.

The Medical College of Georgia is the flagship medical school of the University System of Georgia, the state's only public medical school, and one of the top 10 largest medical schools in the United States. Established in 1828 as the Medical Academy of Georgia, MCG is the oldest and founding school of Augusta University and played a role in the establishment of the American Medical Association and the standardization of medical practices. It is the third-oldest medical school in the Southeast and the 13th oldest in the nation. With 22 departments, it offers both a Doctor of Medicine (MD) as well as MD-PhD, MD-MPH, and MD-MBA degrees. Its national ranking in research is 75, and its ranking in primary care is 91, both out of 191 ranked medical schools.