Omar Rodriguez Lopez & John Frusciante is a collaborative studio album by American artists Omar Rodríguez-López, guitarist of The Mars Volta, and John Frusciante, guitarist of the Red Hot Chili Peppers. The record was digitally released on April 30, 2010. It is the twentieth release by Omar, and their second collaboration following 2005's "0=2" vinyl single, which appears on this record along with its b-side, "0". These two tracks have been available digitally since October 3, 2006. This album was a free download with the option to donate for a period of time. All money raised has gone to "Keep Music in Schools". The album can now be downloaded for $3.99.

Omar Alfredo Rodríguez-López is a Puerto Rican guitarist and songwriter. He has formed or played in several bands, including The Mars Volta, At the Drive-In, Antemasque, and Bosnian Rainbows. He was the bassist for the dub band De Facto. He has embarked on a solo career, both in studio and in concert, frequently described as experimental, avant-garde, or progressive. He has also collaborated with numerous artists, such as Damo Suzuki, John Frusciante, El-P, Mon Laferte and Calle 13.