Omega the Unknown is an American comic book published by Marvel Comics from 1976 to 1977, featuring the eponymous fictional character. The series, written by Steve Gerber and Mary Skrenes and illustrated by Jim Mooney, ran for 10 issues before cancellation for low sales. Despite its short run, it has endured as a cult classic due to its intriguing characters and unusual storytelling. A 10-issue series revamping the character was published from 2007 to 2008, written by novelist Jonathan Lethem and illustrated by Farel Dalrymple.

Stephen Ross Gerber was an American comic book writer and creator of the satiric Marvel Comics character Howard the Duck. Other works include Man-Thing, Omega the Unknown, Marvel Spotlight: "Son of Satan", The Defenders, Marvel Presents: "Guardians of the Galaxy", Daredevil and Foolkiller. Gerber often included lengthy text pages in the midst of comic book stories, such as in his graphic novel, Stewart the Rat. Gerber was posthumously inducted into the Will Eisner Comic Book Hall of Fame in 2010.