The Omni Parker House is a historic hotel in Boston, Massachusetts, founded in 1855. The current hotel structure dates to 1927. Located at the corner of School Street and Tremont, not far from the seat of the Massachusetts state government, the hotel has long been a rendezvous for politicians. The Omni Parker House is a member of Historic Hotels of America, the official program of the National Trust for Historic Preservation.

Historic Hotels of America is a program of the National Trust for Historic Preservation that was founded in 1989 with 32 charter members; the program accepts nominations and identifies hotels in the United States that have maintained their authenticity, sense of place, and architectural integrity.