"On the Road Again" is a song recorded by the American blues rock group Canned Heat in 1967. A driving blues rock boogie, it was adapted from earlier blues songs and includes mid-1960s psychedelic rock elements. Unlike most of Canned Heat's songs from the period which were sung by Bob Hite, second guitarist and harmonica player Alan Wilson provides the distinctive high pitched vocal, sometimes described as a falsetto.

Canned Heat is an American blues and rock band that was formed in Los Angeles in 1965. The group has been noted for its efforts to promote interest in blues music and its original artists. It was launched by two blues enthusiasts Alan Wilson and Bob Hite, who took the name from Tommy Johnson's 1928 "Canned Heat Blues", a song about an alcoholic who had desperately turned to drinking Sterno, generically called "canned heat". After appearances at the Monterey and Woodstock festivals at the end of the 1960s, the band acquired worldwide fame with a lineup of Hite (vocals), Wilson, Henry Vestine and later Harvey Mandel, Larry Taylor (bass), and Adolfo de la Parra (drums).