One True Thing is a 1998 American drama film directed by Carl Franklin. It tells the story of a woman in her 20s who is forced to put her life on hold in order to care for her mother, who is dying of cancer. The script was adapted by Karen Croner from the novel by Anna Quindlen, with the story being based on Quindlen's own struggle with the death of her mother, Prudence Pantano Quindlen, from ovarian cancer in 1972.

Carl Franklin is an American filmmaker. Franklin is a graduate of University of California, Berkeley, and continued his education at the AFI Conservatory, where he graduated with an M.F.A. degree in directing in 1986.