Onisaburo Deguchi , born Ueda Kisaburō 上田 喜三郎 (1871–1948), is considered one of the two spiritual leaders of the Ōmoto religious movement in Japan.

Oomoto , also known as Oomoto-kyo , is a religion founded in 1892 by Deguchi Nao (1836–1918), often categorised as a new Japanese religion originated from Shinto. The spiritual leaders of the movement have always been women within the Deguchi family; however, Deguchi Onisaburō (1871–1948) has been considered an important figure in Omoto as a seishi. Since 2001, the movement has been guided by its fifth leader, Kurenai Deguchi.