Onondaga Lake is located in Central New York, immediately northwest of and adjacent to Syracuse, New York. The southeastern end of the lake and the southwestern shore abut industrial areas and expressways; the northeastern shore and northwestern end border a series of parks and museums.

Syracuse is a city in and the county seat of Onondaga County, New York, United States. With a population of 148,620 and a metropolitan area of 662,057, it is the fifth-most populated city and 13th-most populated municipality in the state of New York.