Operation Medusa was a Canadian-led offensive during the second Battle of Panjwaii of the War in Afghanistan. The operation was fought primarily by the 1st Battalion, The Royal Canadian Regiment Battle Group and other elements of the International Security Assistance Force, including A Co, 2-4 Infantry BN, 4th BDE, 10th Mtn Division, supported by the Afghan National Army and a team from the United States Army's 1st Battalion, 3rd Special Forces Group (Airborne) augmented by C Company, 2nd Battalion, 87th Infantry Regiment of the 10th Mountain Division. Its goal was to establish government control over an area of Kandahar Province centered in the district of Panjwayi some 30 kilometres (19 mi) west of Kandahar city. A tactical victory, it resulted in the deaths of 12 Canadian soldiers; five during the major combat operations, five in bombings, and two in a mortar/RPG attack during the reconstruction phase of the operation. Fourteen British military personnel were also killed when their plane crashed. Despite suffering a brutal battlefield defeat, the Taliban retained their presence in Kandahar province and did not lose their will to fight, leading to the subsequent Operation Falcon Summit. Nonetheless, Operation Medusa was at the time the most significant land battle ever undertaken by NATO.

The Battle of Panjwaii was fought in mid-2006 with primarily Canadian and Afghan soldiers, supported by small elements of Dutch, American, and British forces against the Taliban. There were two separate times in which the forces were involved in heavy fighting in the region. The first phase was fought in July 2006, and the second encounter lasted from September to October 2006.