The Ophites, also called Ophians, were a Christian Gnostic sect depicted by Hippolytus of Rome in a lost work, the Syntagma.
The Brazen Serpent (illustration from a Bible card published 1907 by Providence Lithograph Company)
Agnolo Bronzino, Il serpente di bronzo, from the chapel of Eleonora of Toledo, Florence, Palazzo Vecchio
William Blake, The Temptation and Fall of Eve, 1808 (illustration of Milton's Paradise Lost)
Titelkupfer Index librorum prohibitorum
The Sethians were one of the main currents of Gnosticism during the 2nd and 3rd century AD, along with Valentinianism and the Basilidians. According to John D. Turner, it originated in the 2nd century
Ophites
…has mistakenly transposed this and two other sections, beginning his treatise on heresies with the Ophites, and making the Ophites, Cainites, and Sethians pre-Christian sects. The section of Hippolytus appears to have given a condensed account of the mythological story told by Irenaeus. In giving the name…
Seth. Patriarchs line in iconostasis. Zhdan Dementiev, Vologda. Cathedral of the Assumption, St. Cyril-Belozersky Monastery. Museum of Cyril Belozersky Monastery.