Opie and Anthony's Traveling Virus was a stand-up comedy tour hosted by American radio personalities Gregg "Opie" Hughes and Anthony Cumia that featured a roster of comedians from their radio show, Opie and Anthony. There were three editions of the tour between 2006 and 2008; the first consisted of 4 dates, the second had 8 dates, and the third consisted of a single show.

Gregg Hughes better known by his air name Opie, is an American radio personality and podcast host best known as the former co-host of the Opie and Anthony radio show that aired from 1995 to 2014 with Anthony Cumia and comedian Jim Norton. From 2014 to 2016, Hughes and Norton stayed at SiriusXM as co-hosts of Opie with Jim Norton. In October 2016, Hughes became the host of his own show, The Opie Radio Show, which lasted until his firing, for filming an employee as he used the toilet, on July 7, 2017.