Oppelo AH-pə-loh is a city in Conway County, Arkansas, United States. The population was 781 at the 2010 census.

Conway County is a county located in the U.S. state of Arkansas. Created as Arkansas's 11th county on October 20, 1825, Conway County has four incorporated municipalities, including Morrilton, the county seat and most populous city. The county is also the site of numerous unincorporated communities and ghost towns. The county is named for Henry Wharton Conway, a politician from a powerful political family who served as the delegate from the Arkansas Territory to the U.S. Congress from 1823 to 1827.