Opuwo is the capital of the Kunene Region in north-western Namibia. The town is situated about 720 km north-northwest of the capital Windhoek, and has a population of around 12,300 (2023). It is the commercial hub of the Kunene Region.

Kunene is one of the fourteen regions of Namibia. Its capital is Opuwo, its governor is Marius Sheya. The region's name comes from the Kunene River which forms the northern border with Angola. Besides the capital Opuwo, the region contains the municipality of Outjo, the town Khorixas and the self-governed village Kamanjab. Kunene is home to the Himba people, a subtribe of the Herero, as well as to Damara people and Nama people. As of 2020, Kunene had 58,548 registered voters.