The Equestrian Order of the Holy Sepulchre of Jerusalem, also called Order of the Holy Sepulchre or Knights of the Holy Sepulchre, is a Catholic order of knighthood under the protection of the Holy See. The Pope is the sovereign of the order. The order creates canons as well as knights, with the primary mission to “support the Christian presence in the Holy Land.” It is an internationally recognised order of chivalry. The order today is estimated to have some 30,000 knights and dames in 60 lieutenancies around the world. The Cardinal Grand Master has been Fernando Filoni since 2019, and the Latin Patriarch of Jerusalem is ex officio the Order's Grand Prior. Its headquarters are situated at the Palazzo Della Rovere and its official church in Sant'Onofrio al Gianicolo, both in Rome, close to Vatican City. In 1994, Pope John Paul II declared the Virgin Mary as the order's patron saint under the title "Blessed Virgin Mary, Queen of Palestine."

The Latin Patriarchate of Jerusalem is the Latin Catholic ecclesiastical patriarchate in Jerusalem, officially seated in the Church of the Holy Sepulchre. It was originally established in 1099, with the Kingdom of Jerusalem encompassing the territories in the Holy Land newly conquered by the First Crusade. From 1374 to 1847 it was a titular see, with the patriarchs of Jerusalem being based at the Basilica di San Lorenzo fuori le Mura in Rome. Pope Pius IX re-established a resident Latin patriarch in 1847.