Oregon Route 22 is an Oregon state highway that runs between the Oregon Coast community of Hebo, to a junction with U.S. Route 20 near Santiam Pass in the Cascade Mountains. OR 22 traverses several highways of the Oregon state highway system, including the Three Rivers Highway No. 32, part of the Salmon River Highway No. 39, the Willamina–Salem Highway No. 30, part of the Salem Highway No. 72, and the North Santiam Highway No. 162.

The Oregon Coast is a coastal region of the U.S. state of Oregon. It is bordered by the Pacific Ocean to its west and the Oregon Coast Range to the east, and stretches approximately 362 miles (583 km) from the California state border in the south to the Columbia River in the north. The region is not a specific geological, environmental, or political entity, and includes the Columbia River Estuary.