Oregon Route 99E is an Oregon state highway that runs between Junction City, Oregon and an interchange with I-5 just south of the Oregon/Washington border, in Portland. It, along with OR 99W, makes up a split of OR 99 in the northern part of the state. This split existed when the route was U.S. Route 99, when the two branches were U.S. 99W and U.S. 99E.

Interstate 5 (I-5) in the U.S. state of Oregon is a major Interstate Highway that traverses the state from north to south. It travels to the west of the Cascade Mountains, connecting Portland to Salem, Eugene, Medford, and other major cities in the Willamette Valley and across the northern Siskiyou Mountains. The highway runs 308 miles (496 km) from the California state line near Ashland to the Washington state line in northern Portland, forming the central part of Interstate 5's route between Mexico and Canada.