Osceola is a town in Penn Township, St. Joseph County, in the U.S. state of Indiana. The population was 2,463 at the 2010 Census. It is part of the South Bend–Mishawaka, IN-MI, Metropolitan Statistical Area.

The St. Joseph River is a tributary of Lake Michigan with a length of 206 miles (332 km). The river flows in a generally westerly direction through southern Michigan and northern Indiana, United States, to its terminus on the southeast shore of the lake. It drains a primarily rural farming area in the watershed of Lake Michigan. It was enormously important to Native Americans and greatly aided in the colonial exploration, settlement and administration of New France and the nascent United States as a canoe route between Lake Michigan and the watershed of the Mississippi River.