Osco Drug and Sav-on Drugs were the names of a pair of chain pharmacies that operated in the United States. Osco Drug was founded by the Skaggs family. Alpha Beta grocery store was purchased by American Stores in 1961. Skaggs Drug Centers bought American Stores in 1979 and assumed the American Stores name. Sav-on Drugs was a California-based pharmacy chain that was acquired by Osco's parent company in 1980. Both Osco and Sav-on stores eventually came under the ownership of American Stores, then Albertsons, and finally SuperValu before the stores were sold off.

The Skaggs Family, starting from a small frontier town in southern Idaho, came to have an important impact on merchandising across much of the United States. During most of the 20th century, the Skaggs name was prominent on hundreds of stores throughout the West and Midwest.