Osmosis Jones is a 2001 American live-action/animated action comedy film written by Marc Hyman. Combining live-action sequences directed by the Farrelly brothers and animation directed by Piet Kroon and Tom Sito, the film stars the voices of Chris Rock, Laurence Fishburne, David Hyde Pierce, Brandy Norwood, and William Shatner alongside Molly Shannon, Chris Elliott, and Bill Murray in live-action roles. It follows the title character, an anthropomorphic white blood cell, as he teams up with a cold pill to protect his unhealthy human host from a villainous, highly contagious virus called "the Red Death".

Peter Farrelly and Bobby Farrelly, collectively referred to as the Farrelly brothers, are American screenwriters and directors. They have made eleven films together, including Dumb and Dumber, Outside Providence, and There's Something About Mary.