Osoyoos is the southernmost town in the Okanagan Valley in British Columbia between Penticton and Omak. The town is 3.6 km (2.2 mi) north of the United States border with Washington state and is adjacent to the Osoyoos Indian reserve. The origin of the name Osoyoos was the word sw̓iw̓s meaning "narrowing of the waters" in the local Okanagan language (Syilx'tsn). The "O-" prefix is not indigenous in origin and was attached by settler-promoters wanting to harmonize the name with other place names beginning with O in the Okanagan region. There is one local newspaper, the Osoyoos Times.

The Regional District of Okanagan-Similkameen (RDOS) is in southern British Columbia, adjacent to the U.S. state of Washington. It is bounded by Fraser Valley Regional District to the west, Thompson-Nicola Regional District and Regional District of Central Okanagan to the north, Regional District of Kootenay Boundary to the east, and by Okanogan County, Washington to the south. At the 2011 census the population was 80,742. The district covers a land area of 10,413.44 square kilometres (4,020.65 sq mi). The administrative offices are in the City of Penticton.