The Ospedale degli Innocenti 'Hospital of the Innocents', also known in old Tuscan dialect as the Spedale degli Innocenti, is a historic building in Florence, Italy. It was designed by Filippo Brunelleschi, who received the commission in 1419 from the Arte della Seta. It was originally a children's orphanage. It is regarded as a notable example of early Italian Renaissance architecture. The hospital, which features a nine bay loggia facing the Piazza SS. Annunziata, was built and managed by the "Arte della Seta" or Silk Guild of Florence. That guild was one of the wealthiest in the city and, like most guilds, took upon itself philanthropic duties.

The guilds of Florence were secular corporations that controlled the arts and trades in Florence from the twelfth into the sixteenth century. These Arti included seven major guilds, five middle guilds and nine minor guilds. Their rigorous quality control and the political role in the commune that the Arti Maggiori assumed were formative influences in the history of Florence, which became one of the richest cities of late medieval Europe.