Osthofen is a town in the middle of the Wonnegau in the Alzey-Worms district in Rhineland-Palatinate, Germany. Since 1 July 2014 it is part of the Verbandsgemeinde Wonnegau. Osthofen was raised to town on 24 October 1970.

Rhenish Hesse or Rhine Hesse is a region and a former government district in the German state of Rhineland-Palatinate. It is made up of territories west of the Upper Rhine river that were part of the Grand Duchy of Hesse and its successor in the Weimar Republic, the People's State of Hesse from 1816 to 1945. The hilly countryside is largely devoted to vineyards, comprising the Rheinhessen wine region.