The Otoe are a Native American people of the Midwestern United States. The Otoe language, Chiwere, is part of the Siouan family and closely related to that of the related Iowa, Missouria, and Ho-Chunk tribes.

The Midwestern United States, also referred to as the Midwest or the American Midwest, is one of four census regions of the United States Census Bureau. It occupies the northern central part of the United States. It was officially named the North Central Region by the U.S. Census Bureau until 1984. It is between the Northeastern United States and the Western United States, with Canada to the north and the Southern United States to the south.