Otsego County is a county in the U.S. state of New York located within the Mohawk Valley Region. As of the 2020 census, the population was 58,524. The county seat is Cooperstown. The county's population center is Oneonta. The name Otsego is from a Mohawk or Oneida word meaning "place of the rock." The county is part of the Mohawk Valley region of the state.

The Mohawk Valley region of the U.S. state of New York is the area surrounding the Mohawk River, sandwiched between the Adirondack Mountains and Catskill Mountains, northwest of the Capital District. As of the 2010 United States Census, the region's counties have a combined population of 622,133 people. In addition to the Mohawk River valley, the region contains portions of other major watersheds such as the Susquehanna River.